Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis: A Case Series
نویسندگان
چکیده
منابع مشابه
Cirrhosis originally diagnosed as nonalcoholic steatohepatitis.
A 52-year-old white woman with a presumptive diagnosis of cirrhosis attributed to nonalcoholic steatohepatitis was referred for a liver transplant consultation. The patient reported increased abdominal discomfort, swelling, and lower extremity edema beginning 7 years earlier, as well as intermittent nausea, weakness, and confusion which had increased in frequency during the previous year. While...
متن کاملRisk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis.
CONTEXT In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that presents with cryptogenic cirrhosis. OBJECTIVE To estimate the prevalence of risk factors for N...
متن کاملAntifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) is an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PFD improves liver fibrosis in a mouse model with human NASH-like phenotypes. In this study, we emp...
متن کاملNonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
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Recently, nonalcoholic steatohepatitis (NASH) has been considered to be another cause of liver cirrhosis and hepatocellular carcinoma (HCC). The natural history and prognosis of NASH are controversial. Accordingly, we assessed the clinicopathological features of NASH-associated HCC in our experience and reviewed the literature of NASH-associated HCC. We experienced 11 patients with NASH-associa...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Hepatology
سال: 2020
ISSN: 2225-0719,2310-8819
DOI: 10.14218/jcth.2019.00056